One of the strongest chemical bonds in organic chemistry is formed between carbon and fluorine, giving unique properties to chemical compounds featuring this group. Pharmaceutical researchers are very interested in carbon-fluorine bond containing molecules because of the way they mimic certain behaviors of biological compounds. However, the strength of the carbon-fluorine bond makes it difficult…

A new study by Osaka University scientists shows that non-labeling multiphoton microscopy (NL-MPM) can be used for quantitative imaging of cancer that is safe and requires no resection, fixation or staining of tissues. The report is expected to simplify and reduce the time of cancer diagnosis and can be read in Scientific Reports.

In a joint international study, researchers from Osaka University have partnered with research groups from the United States and Spain to uncover how mutations in a single gene called PKHD1 lead to symptoms associated with a rare kidney and liver disease, ARPKD (autosomal recessive polycystic kidney disease). The findings are expected to lead to novel treatment strategies…

Osaka University researchers, in collaboration with several Japanese companies, translate neuroimaging tools to study renal fibrosis in rat kidney. The technique is expected to replace the invasive biopsies currently used to identify patients at risk of developing chronic kidney disease.