Pain is an unpleasant feeling often caused by intense or damaging stimuli as communicated by a nerve. No one likes it though it does serve as a warning to do something about the pain source. Researchers at the University of Leeds have found a previously unknown mechanism through which pain is signaled by nerve cells. A discovery that could explain the current failings in the drug development process for painkillers and which may offer opportunities for a new approach. In order to control pain, one, must understand how it works.